|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We quantified expression and activity of UPP1 in response to 1α,25(OH)<sub>2</sub>D<sub>3</sub> in young adult mouse colonic cells, human CRC cells (LS174T), and organoids (derived from rectosigmoid biopsy samples of healthy individuals undergoing colonoscopies) using quantitative polymerase chain reaction, immunoblot, and immunocytochemistry assays.
|
29964038 |
2018 |
|
Infarction, Middle Cerebral Artery
|
0.200 |
Biomarker
|
disease |
RGD |
Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase.
|
18457515 |
2008 |
|
Mouth Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
|
12115385 |
2002 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Uridine phosphorylase 1 (UPP1) is a protein-coding gene and has been detected that UPP1 was the higher expression in many solid malignancies, just as head and neck cancers, breast cancer, compared with paired normal tissue.
|
31496029 |
2019 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Uridine phosphorylase 1 (UPP1) is a protein-coding gene and has been detected that UPP1 was the higher expression in many solid malignancies, just as head and neck cancers, breast cancer, compared with paired normal tissue.
|
31496029 |
2019 |
|
Stomach Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.
|
17214321 |
2007 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To clarify the correlation between the expression levels of UPase and dThdPase genes and the clinicopathological factors, mRNA levels of these enzymes were examined by RT-PCR in 43 breast carcinomas.
|
11807789 |
2002 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU.
|
17214321 |
2007 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU.
|
17214321 |
2007 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear.
|
11401323 |
2001 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of TS, DPD, OPRT, TP, and UP were measured by real-time quantitative RT-PCR in samples from 23 consecutive patients with both primary colorectal adenocarcinoma and liver metastasis.
|
15060742 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
|
20226755 |
2010 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
|
20226755 |
2010 |
|
Septicemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expression of S100a8, Upp1, and Mt2a in all three brain regions of young septic rats indicate that these genes may be involved in the first line of response to sepsis in the younger brain.
|
30706174 |
2019 |
|
Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expression of S100a8, Upp1, and Mt2a in all three brain regions of young septic rats indicate that these genes may be involved in the first line of response to sepsis in the younger brain.
|
30706174 |
2019 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in normal tissues.
|
11807789 |
2002 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The DPD, OPRT, TP, and UP mRNA levels were significantly higher in liver metastases than in primary tumor (expression in relation to that of beta-actin mRNA: 0.42 vs 0.16, P=0.00053; 1.4 vs 0.92, P=0.016; 23 vs 11, P=0.00014; 0.36 vs 0.25, P=0.0026; respectively).
|
15060742 |
2004 |
|
Secondary malignant neoplasm of liver
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The DPD, OPRT, TP, and UP mRNA levels were significantly higher in liver metastases than in primary tumor (expression in relation to that of beta-actin mRNA: 0.42 vs 0.16, P=0.00053; 1.4 vs 0.92, P=0.016; 23 vs 11, P=0.00014; 0.36 vs 0.25, P=0.0026; respectively).
|
15060742 |
2004 |
|
Neoplasms
|
0.060 |
PosttranslationalModification
|
group |
BEFREE |
The characterization of the promoter region of UPase has indicated a direct regulation of its expression by the tumor suppressor gene p53.
|
12084455 |
2002 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The activities of uridine phosphorylase in all tumors used showed no changes in response to IFNalpha or Paclitaxel.
|
12359357 |
2002 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Targeted disruption (-/-) of murine uridine phosphorylase (UPase) disrupted the homeostasis of uridine and increased spontaneous tumorigenesis by more than 3-fold.
|
26801745 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Subcutaneous injection of AdMDR1-CD::UPP into the xenografts of mice bearing tumors of A2780/Taxol cells could significantly suppress the tumor growth and prolong survival as compared with the group of A2780 cells.
|
17471022 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, pyrroline-5-carboxylate reductase 2 (PYCR2) and uridine phosphorylase 1 (UPase1) were found to be altered in ESCC.
|
30559182 |
2019 |